Well, this was completely off my radar, but a glance at Kotaku this morning brought this to my attention: a stunning Wiimake of A Boy and His Blob, presented in gorgeous, hand-drawn 2D. (UPDATE: Kotaku posted new screens.) Sounds like it will be a bit of a departure from the original, as well.
Though only us hardcore retro types seem to remember this, A Boy and His Blob was created by David Crane, the man behind many of Activision's great Atari VCS games, including Pitfall! Funny enough, I remember playing A Boy and His Blob on the NES and finding it incredibly difficult. It was more of a puzzle game than an action game, as I recall. I wonder if David Crane is at all involved in this remake? And if he thinks it looks as cool as the rest of us?